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The BIOFIRE System and Your Immune System

The BIOFIRE System provides syndromic infectious disease testing, empowering healthcare professionals to choose the right test the first time. Patients benefit from faster diagnosis and more specific treatment. Clinicians benefit from improved stewardship for antibiotics. Labs improve efficiency and cost savings.

The BioFire Pneumonia Plus Panel (PN panel) tests native sputum (including mini-BAL), endotracheal lavage, and bronchoalveolar liquids (including mini BAL) for 33 clinically important pathogens and resistance genes to antimicrobials within one hour.

Respiratory

The burning of biomass (wood, plants and other organic material) produces gaseous pollutants and fine particles of matter that negatively impact the respiratory system. Climate change could make it more difficult to reverse the negative effects of forest bioethanol fuel fires to the health of humans.

In the United States wildfire smoke is associated with hospitalizations caused by respiratory illnesses like asthma, COPD, and lung cancer. Additionally, this kind of air pollution is a risk factor for cardiovascular diseases and a major cause of illness for the most vulnerable population that include those who are of lower socioeconomic status (SES).

During the COVID-19 epidemic, many communities were exposed to harmful levels of air pollution resulting from wildfires. However the response of public health officials to this environmental issue has been limited and largely focused on educating people regarding symptom management. This knowledge gap is alarming considering the evidence that smoking cigarettes and other sources of poor quality air can cause health problems.

Researchers are currently evaluating the best methods to safeguard public health during future events similar to this. NIH is funding research on this crucial public health issue through the BLUE CORAL study and its successor FIRE CORAL.

For the first time the study is a prospective cohort study that will evaluate long-term effects of exposure to smoke from wildfires and other sources. FIRE CORAL is recruiting adult participants who are hospitalized for the index episode of COVID-19 who are fluent in English or Spanish and are not pregnant. The protocol for FIRE CORAL includes a battery of in-person assessments objectively measuring pulmonary function testing and lung imaging, as well as functional assessment.

The lungs are the most sensitive to the effects of smoke and other particles because they can trigger or worsen chronic respiratory illnesses such as emphysema, asthma and COPD, and increase the risk of pneumonia. A number of steps can be taken to prevent or lessen the negative health effects resulting from exposures to smoke, which includes avoiding outdoor activities when possible and using the EPA's "N95" mask, which is designed to catch fine particles.

Smoking can cause irritation to the eyes and throat, and can cause the nose to run. To reduce the symptoms the lungs must be flushed with plenty of fluids and taking medications that reduce inflammation, such as corticosteroids.

Bloodstream

Bloodstream is the first line of defense against germs that enter your system. Dendritic cells, which are special cells, are like your fire department's call center. they take antigens (molecules that trigger an immune response) from germs that are invading your body and then release proteins that signal other white blood cells to come fight them. The total white blood cells, differentials, and band cells increased after firefighters' fire-fighting duties in comparison to levels after vigorous exercise that did not include firefighting.

Skin

As the wildfires in California produced smoke and ash into the air during fall and winter dermatologists were concerned how that could affect the skin of those exposed to it. Maria Wei is a graduate student at the University of California, Irvine. She examines how extreme wildfire pollution affects the skin. Her research was published on April 22, 2012 in Scientific Reports.

The study of Wei shows that the temperature changes of the skin according to the length of time the body has been exposed. It takes upwards of two hours for a person's skin to reach its flash point -- the temperature at which it starts to burn and then turns to ash. This is the reason why it's essential to not stay near a fire or campfire, and why you must wear protective clothing when you are outside in the midst of a forest fire or even on a hot day.

While it is important to be aware of the dangers of fire-related pollution, there's no way to stop forest fires from happening. Wei is forecasting that the number of people suffering from the consequences of wildfires will increase as climate change causes more and more forests to be burned. This means that more people will have to wear long sleeves, hats and thick moisturizers.

It's also important to know that the atopic dermatitis (itchy skin) that a lot of people suffer from is often exacerbated by wildfire air pollution. The particles in smoke can block pores and cause atopic skin to become worse.

Another issue is the fact that atopic dermatitis tends to make people more sensitive to UV light, which may be aggravated by wildfire smoke. This could lead to people seeking out tanning salons and apply a tan with less protection.

A treatment with ice and fire could help to reduce atopic conditions however, it isn't recommended for anyone with an open wound or rash. This treatment is not recommended for patients with active acne or if you are pregnant or nursing. The IS Clinical Fire & Ice Facial located at Novuskin Las Vegas' premier membership MedSpa is a results-driven, intensive facial that bridges between the mild facelift and the peel, with no any downtime. It's designed to rejuvenate the skin, improve rosacea symptoms, decrease acne scarring, reduce lines and wrinkles, and stimulate cell renewal. It's an amazing treatment to give yourself a radiant glow.

Infections

The human body is a complex network of organs and tissues that work to shield us from infection. Infections are caused by microscopic microorganisms like viruses, bacteria, parasites and fungus that infiltrate healthy cells and cause them to reproduce out of control. Your immune system may react by displaying symptoms of illness. These symptoms can range from a runny nose to an upset stomach and can also include swelling of lymph glands or a rash. The type of infection and its location can affect the severity of your symptoms.

Infections can be spread in a variety of ways, but they are most often spread through droplets in the air that remain after a sniff or cough. Bacterial diseases such as tuberculosis and strep throat meningococcal disease and Legionnaires disease spread through this method, along with some viral infections, bio fuel fires ethanol indoor bioethanol fireplace insert (webkey.co.kr) such as the common cold and influenza. Certain bacteria-related infections, like skin infections and sexually transmitted diseases (STIs) like gonorrhea and Chlamydia, can be transmitted through contact with infected tissue or mucous membranes as well as indirect contact with contaminated surfaces. Some bacterial diseases are transmitted by bugs like mosquitoes, ticks or fleas, and are spread by bites from these bugs you.

Some parasites and viruses are small enough to get into your bloodstream and infect your cells, which leads to serious illnesses like the common cold and AIDS. Fungi can cause a variety of skin ailments, like ringworm and athlete's foot. Some are a threat to the lungs and nervous system, like the rabies virus.

The BioFire Panel employs our revolutionary FilmArray Technology to test the sputum and bronchoalveolar fluid samples to provide a complete list of pathogens involved in upper respiratory infection. The kit includes the reagent pouch which stores all the necessary chemicals to perform reverse transcription PCR, nested multiplex PCR and detection with a single device. It's a simple solution to help clinicians syndromicly identify and treat patients with different respiratory symptoms. The test has been granted an Emergency Use Authorization. It is available in bioMerieux CLIA medium and high complexity labs.